-Provides fast and more efficient clarification of high density pretreated feed streams
-Enables processing in a significantly reduced footprint with reduced flushing requirements
-Eliminates the need for centrifugation
-Fully scalable from lab to process scale
DARMSTADT, Germany, Sept. 17, 2013 /PRNewswire/ -- Merck Millipore, the Life Science division of Merck, today introduced the Clarisolve® depth filter for single-stage clarification of pretreated feed streams. The Clarisolve® depth filter is a novel clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.
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Delivering improved volumetric capacity and reduced turbidity over any currently available depth filtration technologies, Clarisolve® depth filters process pretreated feeds in a significantly reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve® depth filters eliminates the need for centrifugation which enables implementation of a fully single-use process train, and also considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.
"Until now, higher titers coming from upstream bioreactors have posed a challenge to conventional approaches to clarification," described Vin Donovan, Vice President of Biopharm Process Solutions, Merck Millipore. "With Clarisolve® depth filters, our customers can now take full advantage of high density pretreated feed streams and improve overall process economics."
Merck Millipore has also developed a cationic pDADMAC (poly diallyldimenthyl ammonium chloride) flocculation reagent targeted for biopharmaceutical applications which can be used as a pretreatment in combination with the Clarisolve® depth filters. pDADMAC treatment, in combination with Clarisolve® depth filters, provides an effective solution for harvesting high cell density cultures and can be easily incorporated into current clarification platforms.
Clarisolve® filters are available from lab, to pilot, to process scale in the industry leading disposable Pod format.
For more information, please visit www.merckmillipore.com/clarisolve.
