PARIS, Sept. 25, 2013 /PRNewswire/ --
- Findings Consistent with Known Post-Prandial Effect of Lyxumia Supporting Combination with Basal Insulin -
Sanofi (EURONEXT : SAN and NYSE : SNY) announced today new GetGoal-L sub-analysis results showing that reductions in HbA1c with Lyxumia® (lixisenatide), when added to basal insulin, were greatest in patients with type 2 diabetes who had well-controlled baseline fasting plasma glucose (FPG). These findings are consistent with the efficacy profile of Lyxumia, which shows a clinical and statistically significant reduction in HbA1c across different patient populations.
The results also showed that reductions in body weight with Lyxumia, when added to basal insulin, were greatest in this group. The GetGoal-L sub-analysis was shared during an oral presentation at the 49th Annual Meeting of the European Association for the Study of Diabetes, in Barcelona, Spain.
"The study showed that Lyxumia is an effective post-prandial glucose lowering option that improves HbA1c levels when added to basal insulin," said Professor Josep Vidal, Endocrinology and Nutrition, University of Barcelona. "We analyzed data from patients who were not at their target HbA1c level, despite controlled fasting plasma glucose, and we found that a treatment regimen that targets post-prandial glucose, as well as fasting plasma glucose, could be an effective choice for these patients."
As type 2 diabetes progresses over time, patients treated with basal insulin may no longer maintain their target HbA1c level (average blood sugar levels over the past 2 to 3 months), despite typically sustaining good control of FPG with basal insulin. For these patients, Lyxumia can significantly reduce HbA1c by primarily reducing post-prandial (after-meal) glucose levels through its complementary action with basal insulin. Targeting both FPG and post-prandial glucose could be an effective way to lower HbA1c in certain patients with type 2 diabetes.
Results of Analysis
This sub-analysis examined 496 patients with type 2 diabetes and inadequate glucose control. Results showed that the addition of lixisenatide to basal insulin treatment, with or without metformin (oral anti-diabetic therapy), reduced overall HbA1c, body weight and post-breakfast self-monitored post-prandial glucose in all groups. These effects were greater in patients with relatively well-controlled baseline FPG levels (below or equal to 6.7 mmol/L; FPG in people without diabetes is ~5.5 mmol/L(Note 1)) compared to those with higher baseline FPG levels (between 6.7 and 8.9 mmol/L, and over 8.9 mmol/L, respectively).
The GetGoal-L sub-analysis abstract is entitled: 'Therapeutic efficacy of lixisenatide added to basal insulin is greater when FPG is well-controlled' (Vidal J, et al. [Abstract no. oral presentation 6]).
