omniture

WuXi AppTec Achieved Strong Growth in First-Half of 2020 with China Sites Resuming Full Operations

2020-08-13 16:49 4887

WuXi AppTec Second-Quarter 2020 Results

Revenue Up 29.4% YoY to RMB4,044 Million
Net Profit Attributable to Owners of the Company Up 111.0% YoY to RMB1,414 Million
Diluted EPS Up 110.3% YoY to RMB0.61
Adjusted Non-IFRS Net Profit Attributable to Owners of the Company Up 43.1% YoY to RMB942 Million
Adjusted Diluted Non-IFRS EPS Up 46.4% YoY to RMB0.41

WuXi AppTec's Results for the First-Half of 2020

Revenue Up 22.7% YoY to RMB7,231 Million
Net Profit Attributable to Owners of the Company Up 62.5% YoY to RMB1,717 Million
Diluted EPS Up 60.9% YoY to RMB0.74
Adjusted Non-IFRS Net Profit Attributable to Owners of the Company Up 28.9% YoY to RMB1,519 Million
Adjusted Diluted Non-IFRS EPS Up 29.4% YoY to RMB0.66

SHANGHAI, Aug. 13, 2020 /PRNewswire/ -- WuXi AppTec Co., Ltd. (stock code: 603259.SH / 2359.HK), a company that provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients, is pleased to announce its reviewed financial results for the first half of 2020 (Reporting Period).

This document serves purely as a summary and is not intended to provide a complete representation of the relevant matters. For further information, please refer to the 2020 first half report and relevant announcements published on the websites of the Shanghai Stock Exchange (www.sse.com.cn) and the Stock Exchange of Hong Kong (www.hkexnews.hk), and the designated media for dissemination of relevant information. Investors are advised to exercise caution and be aware of the investment risks in dealing in the shares of the Company.

All financials disclosed in this press release are prepared based on International Financial Reporting Standards (IFRS).

Second Quarter 2020 Financial Highlights

  • Revenue grew 29.4% YoY to RMB4,044 million. Our laboratories and manufacturing facilities in China resumed full operations and were met with an increased demand from overseas customers. Consequently, we achieved strong revenue growth in the second quarter, driven by robust demand, increase in capacity utilization and efficient operations.
    - Our China-based laboratory services realized revenue of RMB2,060 million, representing a YoY growth of 31.5%.
    - Our CDMO/CMO services realized revenue of RMB1,314 million, representing a YoY growth of 43.9%.
    - Our U.S.-based laboratory services realized revenue of RMB394 million, representing a YoY growth of 0.7%.
    - Our clinical research and other CRO services realized revenue of RMB271 million, representing a YoY growth of 7.4%.
  • IFRS gross profit grew 27.1% YoY to RMB1,562 million. Gross profit margin was 38.6%, lower than the 39.3% achieved in the same period last year[1], mainly because of: (1) the impact of COVID-19 on our U.S.-based laboratory services and clinical research services business, and (2) an increase in share-based compensation expenses.
  • Non-IFRS gross profit grew 31.6% YoY to RMB1,694 million. Non-IFRS gross profit margin was 41.6% compared to 40.9% for the same period in 2019 and increased significantly compared with First Quarter 2020, mainly because: (1) our China-based laboratory services and CDMO/CMO services segments resumed at full operating capacity and secured more projects from overseas customers, offsetting the impact of COVID-19 on our U.S.-based laboratory services and clinical research services; and (2) we continued to gain efficiency through increased capacity utilization and efficient operations.
  • EBITDA grew 79.6% YoY to RMB1,854 million.
  • Adjusted EBITDA grew 22.7% YoY to RMB1,415 million.
  • Net profit attributable to owners of the Company grew 111.0% YoY to RMB1,414 million. Fair value gain of our investment portfolio increased from RMB134 million in the second quarter of 2019 to RMB1,044 million in the same period this year.
  • Adjusted Non-IFRS net profit attributable to owners of the Company grew 43.1% YoY to RMB942 million. The growth rate significantly accelerated compared with that of First-Quarter 2020.
  • Diluted Non-IFRS EPS increased by 110.3% versus the same period last year and adjusted diluted Non-IFRS EPS increased by 46.4%.[2]

[1] If prepared under Accounting Standard for Business Enterprises of PRC, the gross profit grew 27.7% YoY to RMB1,570 million. Gross profit margin was 38.8%, lower than the 39.4% achieved in the same period last year.

[2] Three months ended June 30, 2019 and three months ended June 30, 2020, we had a fully-diluted weighted average share count of 2,284 million and 2,302 million ordinary shares, respectively.

First Half of 2020 Financial Highlights

  • Revenue grew 22.7% YoY to RMB7,231 million, attributable to the timely implementation of our Business Continuity Plan, as well as the strong growth of our China-based laboratory services and CDMO/CMO services in response to the increased demand from our overseas customers.
    - Our China-based laboratory services realized revenue of RMB3,780 million, representing a YoY growth of 26.5%. 
    - Our CDMO/CMO services realized revenue of RMB2,162 million, representing a YoY growth of 25.8%. 
    - Our U.S.-based laboratory services realized revenue of RMB782 million, representing a YoY growth of 10.1%.
    - Our clinical research and other CRO services realized revenue of RMB500 million, representing a YoY growth of 5.9%.
  • IFRS gross profit grew 16.4% YoY to RMB2,659 million. Gross profit margin was 36.8%, lower than the 38.7% achieved in the same period last year[3], mainly because of: (1) the impact of COVID-19 on our China-based laboratory services (Q1), U.S.-based laboratory services (Q2) and clinical research services (Q1 & Q2) business; and (2) an increase in share-based compensation expenses.
  • Non-IFRS gross profit grew 21.7% YoY to RMB2,918 million. Non-IFRS gross profit margin was 40.1%, compared to 40.4% during the same period in 2019. We implemented our Business Continuity Plan early on and were successful in mitigating the negative impact of COVID-19 on our business. Our Non-IFRS gross profit margin was largely in line with that of the First Half 2019.
  • EBITDA grew 47.9% YoY to RMB2,600 million.
  • Adjusted EBITDA grew 20.7% YoY to RMB2,450 million.
  • Net profit attributable to owners of the Company grew 62.5% YoY to RMB1,717 million. Fair value gain of our investment portfolio increased from RMB55 million loss in the first half of 2019 to RMB939 million gain in the same period this year.
  • Adjusted Non-IFRS net profit attributable to owners of the Company grew 28.9% YoY to RMB1,519 million.
  • Diluted IFRS EPS increased by 60.9% versus the same period last year and adjusted diluted Non-IFRS EPS increased by 29.4%.[4]

[3] If prepared under Accounting Standard for Business Enterprises of PRC, the gross profit grew 16.7% YoY to RMB2,668 million. Gross profit margin was 36.9%, lower than the 38.8% achieved in the same period last year.

[4] Six months ended June 30, 2019 and six months ended June 30, 2020, we had a fully-diluted weighted average share count of 2,284 million and 2,301 million ordinary shares, respectively.

First Half 2020 Business Highlights

  • During the reporting period, we added about 600 new customers, increasing our active customer count to more than 4,000. Our "long-tail" strategy and "Follow the Customer/Follow the Project/Follow the Molecule" business model continued to perform very well.
    - Our global platform continued to enable innovation worldwide. During the reporting period, our overseas customers contributed RMB5,546 million revenue, representing a YoY growth of 22.3%. Our China customers contributed RMB1,686 million revenue, representing a YoY growth of 23.9%.
    - We continued to expand our customer base and retain existing customers. During the reporting period, our existing customers contributed RMB6,831 million revenue, representing a YoY growth of 22.5%. Our newly added customers contributed RMB401 million revenue, representing a YoY growth of 26.7%.
    - We continued to execute our "long-tail" strategy and increased our support to large global pharmaceutical companies. During the reporting period, our global "long-tail" customers and China-based customers contributed RMB4,926 million revenue, representing a YoY growth of 28.7%. The top 20 global pharmaceutical companies contributed RMB2,305 million revenue, representing a YoY growth of 11.6%.
    -We continued to increase customer conversion and enhance synergies across our platform. During the reporting period, customers using services from more than one of our business units contributed RMB6,151 million revenue, representing a YoY growth of 31.8%.
  • In small molecule drug discovery services, leveraging our large-scale and experienced global small molecule chemical drug research and development teams, we continued to assist global customers in discovering pre-clinical drug candidates and patent applications, with multiple research papers published in leading scientific journals.
  • We anticipated the industry trend early on and empowered our global customers with cutting-edge technology. To highlight a few examples, we offered:
    - New mechanism of actions (MOA): our PROTAC platform maintained strong momentum, enabling over 40 biotech customers and resulting in revenue growth of over 23%.
    - New modalities: we further strengthened our oligonucleotide and peptide drug discovery and development capabilities in our China-based laboratory services, providing services to over 1,000 oligonucleotide and peptide projects, including library synthesis, custom synthesis, modification, route development, and kg scale non-GMP manufacturing.
  • With the comprehensive integration of our DNA-encoded library (DEL), protein production and structure-based drug design capabilities, our Target-to-Hit platform enabled over 300 customers globally, creating incremental business opportunities for our downstream business units.
  • In our success-based drug discovery service unit, we submitted IND filings for 13 new chemical entities (NCE) for our customers and obtained 9 CTAs. As of June 30, 2020, we have cumulatively submitted 98 NCE IND filings with the National Medical Products Administration (NMPA) for our customers and obtained 66 CTAs. As of June 30, 2020, there is 1 project in Phase III clinical trial, 8 projects in Phase II clinical trials, and 54 projects in Phase I clinical trials.
  • Our safety assessment services achieved very strong growth due to a surge in customer demand and increased capacity.
  • We leveraged our platform to prepare and facilitate submissions of our customers' IND packages through our WuXi IND (WIND) service. During the reporting period, we signed 50 integrated WIND packages with our customers, helping many of our global and China-based customers submit their IND packages and obtain clinical trial approval from the U.S. Food and Drug Administration (FDA) under the Electronic Common Technical Document (eCTD) format.
  • We added over 260 new molecules into our small molecule CDMO/CMO services pipeline. In addition, our "Follow the Molecule" strategy resulted in 5 new commercial projects. We provided CDMO services to over 1,100 active projects, including 42 projects in Phase III clinical trials, and we provided commercial manufacturing services for 26 approved drugs. In serving China-based customers, we have 26 Marketing Authorization Holder (MAH) projects in progress, including 4 commercial projects.
  • Our cell and gene therapies CDMO services enabled customers globally. During the reporting period:
    - Our laboratories and facilities in the U.S. provided services for 31 clinical stage projects, including 22 projects in Phase I clinical trials and 9 projects in Phase II/III clinical trials. In July 2020, we signed a late-phase manufacturing contract with a customer for its allogeneic cell therapy product, which is currently undergoing FDA priority review. As more of our customers enter late stage development in 2021, we expect our capacity utilization rate to further increase.
    - Our laboratories and facilities in China added more customers and projects. In addition, we entered into a long-term partnership with our first customer for a commercial manufacturing project.
  • Our clinical research services continued to enable customers in China and the U.S. During the reporting period:
    - Our clinical development team provided services to more than 130 projects for our clients in China and the U.S. and completed the registration trials for 5 products.
  • Our site management organization (SMO) team assisted in the market approval of 12 products for our customers, including the approval of a surgical implant for the treatment of glaucoma based on real world evidence in China.
  • First Half 2020 capabilities enhancement and capacities expansion:
    - In January 2020, we started construction of a new drug product development and production facility at our CDMO subsidiary STA's Wuxi site. This facility will not only improve the development and production capacity of solid dosages, but will also be capable of sterile drug product development, clinical trial material production and commercial scale manufacturing.
    - Our high-potency active pharmaceutical ingredient (API) manufacturing facility, large-scale oligonucleotide API manufacturing facility and large-scale peptide API manufacturing facility in Changzhou, China began operations, supporting the process R&D and manufacture of small molecules, as well as oligonucleotide and peptide APIs from preclinical to commercial.
    - Our Philadelphia cell and gene therapies facility expanded its service capabilities by offering a fully integrated adeno-associated virus (AAV) Vector Suspension Platform and a fully integrated Closed Process CAR-T Cell Therapy Platform, which will help our customers accelerate the timeline for cell and gene therapy development, manufacturing and release.
    - Our Wuxi City cell therapy CDMO facility began operations, providing services to multiple customers. We launched our AAV adherent manufacturing platform and started to build an AAV Vector Suspension Platform in China.
    - In July 2020, our newly-built Chengdu research and development center began operations.

Management Comment

Dr. Ge Li, Chairman and CEO of WuXi AppTec, said, "We achieved strong growth in the first half of 2020, in spite of the impact of COVID-19 on our China-based laboratory services in the first quarter, U.S.-based laboratory services in the second quarter, and clinical research services. Our revenue grew 22.7% year-over-year to RMB7,231 million and our adjusted Non-IFRS net profit grew 28.9% year-over-year to RMB1,519 million. Strong performance from our China-based laboratory services and CDMO/CMO services mitigated any challenges faced by our U.S.-based laboratory services and clinical research services."

"Our global enabling platform and 'Follow the Customer/Follow the Project/Follow the Molecule' strategy continued to perform very well. China-based laboratory services and CDMO/CMO services resumed full operations and achieved robust growth, attributable to increased business opportunities and improved utilization and efficiency. Our U.S.-based laboratory services, clinical research and other CRO services segments, although severely impacted by COVID-19, still realized revenue growth and our backlog continued to improve quarter-over-quarter. In regard to the Company's financial position, in August 2020 we completed the placing of new H shares, receiving approximately HK$7.29 billion in net proceeds, providing the Company with a strong balance sheet for investments, business expansion and potential M&A."

Dr. Ge Li concluded, "2020 has been a year full of challenges and opportunities. We achieved solid growth in the first half of 2020 as a result of the combined efforts of all our employees and support from our customers globally. We are determined to navigate through the challenges posed by COVID-19 in partnership with our global customers, and are committed to working alongside our customers and partners in the global healthcare community to keep the R&D and manufacturing engine humming. The fundamentals of our business remain very strong and we expect to deliver a strong second half. Looking ahead, we will continue to focus on enabling our global partners and doing the right thing for patients in order to realize our vision that 'every drug can be made and every disease can be treated.'"

Reconciliation of Non-IFRS and Adjusted Non-IFRS Net Profit Attributable to Owners of the Company[5]


RMB Million

Three
months
ended June
30, 2020

Three
months
ended June
30, 2019

Six
months
ended June
30, 2020

Six
months
ended June
30, 2019

Profit Attributable to the
owners of the Company

1,414.1

670.3

1,717.2

1,056.8

Add:





      Share-based
compensation expenses

158.7

31.0

275.3

62.7

      Convertible bonds
issuance expenses

1.3

-

2.5

-

      Fair value loss from
derivative component of
convertible bonds

502.1

-

486.8

-

      Foreign exchange
related (gains)/losses

36.1

(18.0)

20.3

81.3

     Amortization of
acquired intangible assets
from merge and acquisition

8.8

7.1

17.6

12.4

Non-IFRS Net Profit
Attributable to the Owners
of the Company

2,121.1

690.3

2,519.6

1,213.2

Add:





      Realized and
unrealized gains from
venture investments

(1,184.3)

(45.6)

(1,013.2)

(54.7)

      Realized and
unrealized share of losses
of joint ventures

5.6

14.0

12.4

20.2

Adjusted Non-IFRS net
profit attributable to the
owners of the Company

942.4

658.6

1,518.7

1,178.7


[5] If the sum of the data below is inconsistent with the total, it is caused by rounding.

 

 

Condensed Consolidated Statement of Profit or Loss[6]


RMB million

Three
months
ended
June
30, 2020

Three
months
ended
June
30, 2019

Six
months
ended
June
30, 2020

Six
months
ended
June
30, 2019

YoY
Change







Revenue 

4,043.9

3,124.9

7,231.4

5,894.4

22.7%

   Cost of services

(2,482.1)

(1,896.5)

(4,572.8)

(3,610.8)

26.6%

Gross profit

1,561.9

1,228.4

2,658.6

2,283.6

16.4%

   Other income

76.0

65.2

128.0

124.9

2.5%

   Other gains and
losses

701.5

238.1

721.8

(22.5)

NA

   Impairment losses
under expected credit
losses (ECL) model,
net of reversal

(12.1)

0.7

(8.1)

(1.2)

 

 

601.5%

   Selling and
marketing expenses  

(155.3)

(103.7)

(274.5)

(208.5)

31.6%

   Administrative
expenses 

(459.0)

(370.3)

(829.3)

(671.2)

23.5%

   Research and
development expenses

(207.5)

(131.9)

(333.4)

(243.6)

36.9%

Operating Profit

1,505.5

926.5

2,063.1

1,261.4

63.5%

   Share of profits
(losses) of associates

59.1

(114.3)

(17.9)

73.0

-124.5%

   Share of losses of
joint ventures

(5.6)

(13.9)

(12.4)

(20.2)

-38.6%

   Finance costs

(52.8)

(20.1)

(110.8)

(32.8)

238.3%

Profit before tax

1,506.1

778.1

1,922.0

1,281.5

50.0%

   Income tax expense

(83.8)

(86.7)

(194.5)

(176.5)

10.2%

Profit for the period

1,422.4

691.4

1,727.5

1,105.0

56.3%







Attributable to:






   Owners of the
Company

1,414.1

670.3

1,717.2

1,056.8

62.5%

   Non-controlling
interests

8.3

21.1

10.3

48.2

-78.6%


1,422.4

691.4

1,727.5

1,105.0

56.3%


[6] If the sum of the data below is inconsistent with the total, it is caused by rounding.


 

 

Condensed Consolidated Statement of Profit or Loss (continued)[7]


RMB

Three
months
ended
June
30, 2020

Three
months
ended
June
30, 2019

Six
months
ended
June
30, 2020

Six
months
ended
June
30, 2019

YoY
Change







Weighted
average number
of ordinary
shares for the
purpose of
calculating
(express in
shares)






– Basic

2,284,251,336

2,281,010,674

2,283,360,465

2,280,549,699

0.1%

– Diluted

2,301,825,513

2,283,904,160

2,300,934,641

2,283,904,162

0.7%







Earnings per
share attributable
to ordinary equity
holders of the
parent
(expressed in
RMB per share)[8]






– Basic

0.61

0.29

0.75

0.46

63.0%

– Diluted

0.61

0.29

0.74

0.46

60.9%


[7] If the sum of the data below is inconsistent with the total, it is caused by rounding.

[8] In June 2020, pursuant e shareholders' general meeting, the Company issued 4 shares for every 10 shares
of the Company by way of capitalization of reserve. In accordance with the regulations of the China Securities
Regulatory Commission, the Company has adjusted the basic earnings per share and diluted earnings per
share for the comparative period according to the 2019 Profit Distribution Plan.

 

 

Condensed Consolidated Statement of Financial Position[9]


RMB million

Jun 30,

December 31,


2020

2019




Non-Current Assets



  Property, plant and equipment

8,170.1

7,666.0

  Right of use assets

1,524.1

1,564.4

  Biological assets

402.0

360.3

  Goodwill

1,369.3

1,362.2

  Other intangible assets

486.7

495.9

  Interest in associates

857.5

768.3

  Interest in joint ventures

47.6

25.2

  Deferred tax assets

307.6

262.2

  Financial assets at fair value through
    profit or loss (FVTPL)

5,762.5

4,009.1

  Other non-current assets

578.3

62.4

  Amount Due from Related Parties

0.2

0.2


19,505.9

16,576.1




Current Assets



  Inventories

1,690.5

1,208.3

  Contract costs

140.4

180.2

  Biological assets

362.9

354.0

  Amounts due from related parties

15.8

13.3

  Trade and other receivables

4,033.9

3,555.9

  Contract assets

454.7

379.4

  Income tax recoverable

1.3

6.3

  Financial assets at FVTPL

1,804.8

1,701.6

  Derivative financial instruments

13.3

36.8

  Pledged bank deposits

3.4

4.0

  Bank balances and cash 

2,848.5

5,223.3


11,369.5

12,663.0




Total Assets

30,875.4

29,239.1


[9] If the sum of the data below is inconsistent with the total, it is caused by rounding.

 

 

Condensed Consolidated Statement of Financial Position (continued)[10]


RMB million

Jun 30,

2020

December 31,

2019




Current Liabilities



  Trade and other payables

3,238.5

3,392.8

  Amounts due to related parties

20.4

24.8

  Derivative financial instruments

55.6

86.4

  Contract liabilities

1,244.6

897.1

  Borrowings

1,787.0

1,809.9

  Income tax payables

254.5

261.4

  Financial liabilities at FVTPL

43.7

19.5

  Lease liabilities

162.8

142.5


6,807.0

6,634.4




Non-Current Liabilities



Borrowings

557.7

762.4

Deferred tax liabilities

211.9

231.1

Deferred income

660.4

667.4

Lease liabilities

1,065.9

1,104.7

Convertible bonds-debt component

1,937.6

1,874.9

Convertible bonds-embedded derivative
component

789.2

298.0

Financial liabilities at FVTPL

-

24.7

Other long-term liabilities

192.5

231.8

Total Non-Current Liabilities

5,415.2

5,195.0




Total Liabilities

12,222.3

11,829.4




Net Assets

18,653.1

17,409.7




Capital and Reserves



  Share capital 

2,311.6

1,651.1

  Reserves

16,220.9

15,661.1

  Equity attributable to owners of the
Company

18,532.5

17,312.3

  Non-controlling interests

120.7

97.5

Total Equity

18,653.1

17,409.7


[10] If the sum of the data below is inconsistent with the total, it is caused by rounding.

About WuXi AppTec

WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients. As an innovation-driven and customer-focused company, WuXi AppTec helps our partners improve the productivity of advancing healthcare products through cost-effective and efficient solutions. With industry-leading capabilities such as R&D and manufacturing for small molecule drugs, cell and gene therapies, and testing for medical devices, WuXi AppTec's open-access platform is enabling more than 4,000 collaborators from over 30 countries to improve the health of those in need – and to realize our vision that "every drug can be made and every disease can be treated." Please visit: http://www.wuxiapptec.com

Forward-Looking Statements

This press release may contain certain "forward-looking statements" which are not historical facts, but instead are predictions about future events based on our beliefs as well as assumptions made by and information currently available to our management. Although we believe that our predictions are reasonable, future events are inherently uncertain and our forward-looking statements may turn out to be incorrect. Our forward-looking statements are subject to risks relating to, among other things, the ability of our service offerings to compete effectively, our ability to meet timelines for the expansion of our service offerings, our ability to protect our clients' intellectual property, unforeseeable international tension, competition, the impact of emergencies and other force majeure. Our forward-looking statements in this press release speak only as of the date on which they are made, and we assume no obligation to update any forward-looking statements except as required by applicable law or listing rules. Accordingly, you are strongly cautioned that reliance on any forward-looking statements involves known and unknown risks and uncertainties. All forward-looking statements contained herein are qualified by reference to the cautionary statements set forth in this section. All information provided in this press release is as of the date of this press release and are based on assumptions that we believe to be reasonable as of this date, and we do not undertake any obligation to update any forward-looking statement, except as required under applicable law.

Non-IFRS Financial Measures

We provide Non-IFRS gross profit, exclude the impact in revenue and cost from effective hedge accounting, share-based compensation expenses and amortization of intangible assets acquired in business combinations, and Non-IFRS net profit attributable to owners of the Company, which exclude share-based compensation expenses, listing expenses and issuance expenses of convertible bonds, fair value gain or loss from derivative component of convertible bonds, foreign exchange-related gains or losses and amortization of intangible assets acquired in business combinations. We also provide adjusted Non-IFRS net profit attributable to owners of the Company and earnings per share, which further exclude realized and unrealized gains or losses from our venture investments and joint ventures. We further provide EBITDA and adjusted EBITDA. Neither of above is required by, or presented in accordance with IFRS. We believe that the adjusted financial measures used in this press release are useful for understanding and assessing our core business performance and operating trends, and we believe that management and investors may benefit from referring to these adjusted financial measures in assessing our financial performance by eliminating the impact of certain unusual, non-recurring, non-cash and non-operating items that we do not consider indicative of the performance of our core business. Such Non-IFRS financial measures, the management of the Company believes, is widely accepted and adopted in the industry the Company is operating in. However, the presentation of these adjusted Non-IFRS financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with IFRS. You should not view adjusted results on a stand-alone basis or as a substitute for results under IFRS, or as being comparable to results reported or forecasted by other companies.

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Source: WuXi AppTec
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