HONG KONG, April 14, 2022 /PRNewswire/ -- Akeso, Inc. (9926.HK) ( "Akeso" ), a China-based biopharmaceutical company focusing on the development and commercialization of innovative therapeutic antibodies for Oncology & Immunology, announced the publication of preclinical results of its PD-1/LAG-3 bi-specific antibody (AK129) at the American Association for Cancer Research (AACR) Annual Meeting 2022. Both in vitro and in vivo preclinical data demonstrated that AK129 has enhanced T cell activation activity with robust anti-tumor activity compared to PD-1 and LAG-3 antibody combo.
Abstract: AK129, an anti-PD1/LAG-3 bi-specific antibody for cancer therapy
https://www.abstractsonline.com/pp8/#!/10517/presentation/17739
AK129, a bi-specific antibody, acts by co-blocking two immune checkpoint molecules co-expressed on T cells, PD-1 and LAG-3. Signaling through PD-1/PD-L1 exerts major effects on cytokines production by T cells, inhibiting the production of IFN-γ and IL-2. LAG-3 is a cell surface molecule expressed on effector T cells and Tregs, which plays a vital role in regulating T cell function to promote tumor immune escape. LAG-3 and PD-1 mediate different signaling pathways, but they may act synergistically to cause effector T cells inactivation and exhaustion. AK129 is being investigated as a cancer immunotherapeutic agent.
Results and observations from AK129's preclinical study support the development of AK129 as a cancer immunotherapeutic agent in the clinic:
Reference
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