HONG KONG, April 14, 2022 /PRNewswire/ -- Akeso, Inc. (9926.HK) ( "Akeso" ), a China-based biopharmaceutical company focusing on the development and commercialization of innovative therapeutic antibodies for Oncology & Immunology, announced the publication of preclinical results of its anti-TIGIT monoclonal antibody (AK127) showing potent preclinical anti-tumor activities at the American Association for Cancer Research (AACR) Annual Meeting 2022.
Abstract:AK127, a novel monoclonal antibody (mAb) targeting T cell immunoreceptor (TIGIT)
https://www.abstractsonline.com/pp8/#!/10517/presentation/17743
AK127 is a novel humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) targeting T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT). AK127 specifically binds to TIGIT and blocks the interaction of TIGIT with its ligands, thus relieving immune suppression and promoting anti-tumor immune response.
Immune checkpoint blocking antibodies achieved great clinical success, yet a large fraction of cancer patients receive minimum benefit from current immunotherapies targeting PD-1 and CTLA-4. As a new multifunctional immune checkpoint molecule, TIGIT holds promise to become an important cancer immune therapy target.
The observations in AK127's preclinical study support the development of AK127 as an anti-tumor agent in the clinic:
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